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Diazepam, in other words Valium, is a prescription medicine available under the brand names Valium, Diastat Acuial, Diastat, and Diazepam intensive.
It is a benzodiazepine derivative. It is available for oral administration in the form of tablets containing 2 mg, 5 mg or 10 mg diazepam.
What is diazepam used for?
It is used to treat anxiety, muscle cramps and panic attacks. Secondly, it is also used to treat epileptic seizures. Finally, it is used during hospitalization to reduce the symptoms of alcohol withdrawal, such as sweating or difficulty sleeping.
You can also take it to help you relax before surgery or other medical or dental treatments.
It comes in the form of tablets, a liquid, or in a rectal tube. In the hospital it can also be given by injection.
How does diazepam work?
This medicine is mainly used to treat episodes of increased seizures (such as cluster or breakthrough seizures) in people who are already taking medicines to control their epilepsy. This medication is only recommended for short term treatment. It is not recommended to take this medicine daily to prevent your attacks. Uncontrolled seizures can lead to severe (possibly fatal) seizures that do not stop (status epilepticus).
This drug is not recommended for children under 6 months of age due to the risk of serious side effects.
This drug works by calming the brain and nerves. It belongs to a class of drugs known as benzodiazepines.
What are the side effects of diazepam?
Before you buy diazepam knowing what the side effects are and how to protect yourself from them is of the utmost importance.
Get emergency medical help if you get any signs of an allergic reaction such as hives, difficult breathing, swelling in your face, lips, tongue, or throat.
This medicine can slow your breathing. A person who is caring for you or near you should seek medical attention if you have slow breathing with long pauses or if you have bluish-colored lips or if you have difficulty waking up.
Common side effects of diazepam can include:
Loss of coordination.
This is not a complete list of the side effects associated with diazepam and others that may occur. Call your doctor for medical advice on all side effects.
What dosages is diazepam prescribed in?
The usual oral dose for anxiety or seizures is 2-10 mg diazepam per day. Initially of the condition, you should take it 2-4 times a day.
The usual rectal dose is 0,2-0,5 mg / kg and depends on the age of the patient.
This medicine can be taken with or without food.
Diazepam is eliminated by the liver and is mainly excreted by the kidneys. Diazepam doses may need to be reduced in patients with abnormal renal function.
How should I take diazepam?
Follow all label directions and read any medication guides or instruction sheets. Your doctor may change your dose from time to time. Use the medicine exactly as prescribed.
This medication should be taken with some caution. Misuse can result in addiction, overdose or death. Keep the medication in a place where others cannot reach it.
Measure liquid drugs carefully. Use the supplied dosing syringe or use a dosing device (not a kitchen spoon).
Diazepam should only be used for a short time. Do not take this medicine for more than 4 months without your doctor's advice.
Do not suddenly stop taking this medicine. Not even when you feel well. Stopping suddenly can lead to more seizures and withdrawal symptoms.
How long does it take for diazepam to work?
The answer to the question "how long does it take for diazepam to work?" is: it depends. The time it takes for this benzodiazepine to work depends on how and what you are using it for. It can be taken by mouth, injection, or rectal gel.
When given by injection, it only takes 5 minutes to show its effects.
When taken as a pill or tablet for anxiety, the effects are felt 15 to 60 minutes after ingestion. However, it can take 2 weeks to feel the full effects.
Rectal gel can be used for patients who have seizures. The effects are noticed soon after administration.
How Long Does Diazepam Work?
If you have just taken this benzodiazepine you may be wondering “how long does diazepam work?”. The amount of time a drug remains active in your body has to do with its half-life. The larger the dose and the more often you take it, the longer the half-life.
The half-life of diazepam is 30 to 56 hours. This means that its effects will continue to be active sometime in between that time frame. However, based on the half-life, it takes about 3 weeks for all metabolites to completely disappear from your body.
There are many variables that can affect how long this drug remains visible in your system. It depends on your metabolism, age, weight and body fat percentage. Exercising a lot and drinking a lot of water can help your body eliminate the metabolites more quickly.
What medications or supplements does diazepam interact with?
Many medications can affect the way this anxiety inhibitor works. Hence, it is very important to inform your doctor about all medicines you are taking, including illegal or recreational drugs, herbal remedies and supplements.
Medicines known to interact with Valium and cause problems include:
Monoamine oxidase inhibitors, or MAO inhibitors (medicines used for depression);
Phenothiazines (medicines used for severe mental illness)
Medicines used for anxiety, including fluoxetine (Prozac);
Sedatives, muscle relaxants and medicines used for sleeping;
Cough and cold medications containing antihistamines;
Narcotic painkillers and barbitures;
Medicines to treat heartburn, including cimetidine (Tagamet) and ranitidine (Zantac);
Medicines to treat fungal infections, including ketoconazole (Nizoral);
Medicines used to treat Parkinson's disease, including levodopa (Larodopa, Sinemet);
Anti-burglary drugs, including valproic acid (Depakene) and phenytoin (Dilantine);
Some heart medications, such as digoxin (Lanoxin) and metoprolol (Lopressor, Toprol XL);
This medicine can make you sleepy and can affect your judgment. Until you know how this medicine affects you, do not drive or operate machinery.
Is Diazepam Addictive?
Benzodiazepines are notorious for developing tolerance and physical dependence. This drug and other benzodiazepines are the most commonly prescribed drugs in the Netherlands for the relief of anxiety symptoms. It has been clinically proven that if these drugs are used for long periods of time, there is a high probability that the patient could become addicted to the drug.
Withdrawal after long-term use will give rise to withdrawal symptoms – a spectrum of clinical disorders seen in users after discontinuation of treatment. The withdrawal symptoms of diazepam are very similar to those of alcohol. Dependence can occur even after short-term use of small amounts. However, using larger doses in the longer term will result in more severe and unpleasant withdrawal symptoms.
How does diazepam withdrawal happen?
Extensive research and studies have been conducted to study the medical aftereffect of the sedative when its use is discontinued. The drug response and physical dependence on the human body was first observed by Hollister and his associates in 1963 while studying the treatment of schizophrenic patients with Valium. It has also been studied that the patients who stop taking the drug often confuse their withdrawal symptoms with their disorders and think that their previous symptoms are returning and therefore resume taking the drug.
The most authentic and solid study of the withdrawal symptoms was conducted by Winokur and his helpers.
The medical literature on diazepam withdrawal symptoms suggests that symptoms occur 11 days after discontinuation of treatment. The symptoms, according to the literature, include psychosis, anxiety and restlessness, motor disorders, seizures and restlessness. A wide spectrum of symptoms were observed. The literature indicates that some patients developed some of the symptoms, while others were diagnosed with the full spectrum of symptoms. The spectrum included symptoms such as disturbed sleep, insomnia, anxiety, depression, hysterical neurosis, heart complaints, back pain, headache and hyperventilation.
Medical advisers suggest a planned and gradual withdrawal of the drug with small reductions in dosages to avoid the above symptoms. Withdrawal is advisable under the watchful eye of a physician or health care professional.
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