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Simvastatin belongs to a group of medicines called “statins”.
Simvastatin is used to lower the blood level of “bad” cholesterol, raise the level of “good” cholesterol and lower triglycerides (a type of fat in the blood).
Simvastatin is also used to lower the risk of stroke, heart attack, and other heart complications in people with diabetes, coronary heart disease, or other risk factors.
Simvastatin is used in adults and children who are at least 10 years old.
Simvastatin, in combination with a proper diet, is used to lower “bad” cholesterol and fats (such as LDL and triglycerides) and to raise “good” cholesterol (HDL) in the blood.
It belongs to a group of medicines known as “statins”.
Simvastatin works by lowering the amount of cholesterol made by the liver. Lowering "bad" cholesterol and triglycerides and increasing "good" cholesterol lowers the risk of heart disease and helps prevent strokes and heart attacks.
In addition to eating a good diet (such as a low-cholesterol/low-fat diet), there are other lifestyle changes that can help this medication work better. These include exercise, weight loss and smoking cessation.
Simvastatin appears to be a very safe drug and it is uncommon to experience side effects. However, different statins can act on people in different ways.
A rare but serious side effect is unexplained muscle pain. This is more likely if you are taking a higher dose of simvastatin. It may occur several weeks or months after you start taking this medicine.
Another very rare side effect is memory loss. This usually goes away when you stop taking the medicine.
The usual adult dose of simvastatin is between 10 mg and 40 mg once a day. For people with very high cholesterol, a higher dose of 80 mg per day may be prescribed.
Your dose will depend on why you are taking it, your cholesterol level, and what other medicines you are taking. Ask your doctor or pharmacist for advice if you are not sure how much to take. Do not reduce your dose without talking to your doctor first.
The usual starting dose in children is 10 mg every evening. Your child's doctor may increase this dose after 4 weeks. The dose is based on your child's age and can be up to a maximum of 40 mg.
Drug interactions can change how your medicines work or increase the risk of serious side effects.
This document does not contain all possible drug interactions. Keep a list of all the medicines you use (including prescription, over-the-counter and herbal products) and share it with your doctor and pharmacist. Do not start, stop or change the dose of any medicine without your doctor's approval.
Some products that may interact with this medicine are “blood thinners” (such as warfarin), cyclosporine, danazol, daptomycin and/or gemfibrozil.
Other medicines may affect the removal of simvastatin from your body, which may affect how simvastatin works. Examples include certain azole antifungals (such as itraconazole, ketoconazole, posaconazole, voriconazole), boceprevir, cobicistat, colchicine, delavirdine, macrolide antibiotics (such as clarithromycin, erythromycin), nefazodone, HIV protease inhibitors (such as nelfinavir, ritonavir), or telithromycin.
The Chinese should not take niacin in doses used to lower cholesterol (1 gram or more) when taking this medication. This can increase the risk of side effects (especially muscle problems). Contact your doctor for more information.
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