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What is Prozac?

Prozac (fluoxetine) is a selective serotonin reuptake inhibitor. It affects certain chemical messengers (neurotransmitters) that communicate between brain cells and helps people with depression, panic, anxiety or obsessive-compulsive symptoms.

Prozac is used to treat major depressive disorder, bulimia nervosa (an eating disorder), obsessive-compulsive disorder, panic disorder, and premenstrual dysphoria disorder.


Why is Prozac prescribed?

Prozac is used to treat depression, panic attacks, obsessive compulsive disorder, a certain eating disorder (bulimia), and a severe form of premenstrual syndrome (premenstrual dysphoria disorder).

This medication can improve your mood, sleep, appetite, and energy levels and can help restore your interest in everyday life. It can reduce anxiety, worry, unwanted thoughts and the number of panic attacks.

Prozac can also reduce the urge to perform repetitive tasks (compulsions such as washing hands, counting, and checking) that interfere with daily life.

Prozac can reduce premenstrual symptoms such as irritability, increased appetite and depression. It can reduce binge eating and purging behavior in bulimia.


How does Prozac work?

Prozac works by preventing the brain from reabsorbing naturally occurring serotonin. Serotonin is involved in mood regulation. In this way, Prozac helps the brain to retain enough serotonin to give you a feeling of well-being. This is a result of better communication between the brain cells.


What Are the Side Effects of Prozac?

Report new or worsening symptoms to your doctor, such as mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or having thoughts about suicide or hurting yourself.

Call your doctor right away if you experience:

  • Blurred vision, tunnel vision, pain or swelling of the eyes or seeing halos around lights
  • Fast or pounding heartbeats, shortness of breath and sudden dizziness (as if you might pass out)
  • Low levels of sodium in the body with symptoms of headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination,
  • Severe nervous system reaction with symptoms such as very stiff (rigid) muscles, high fever, sweating, confusion, fast or irregular heartbeat, tremors, feeling like you might pass out.


Seek immediate medical attention if you have symptoms of serotonin syndrome such as agitation, hallucinations, fever, sweating, shivering, rapid heartbeat, muscle stiffness, convulsions, loss of coordination, nausea, vomiting, or diarrhea.


Common Prozac side effects may include:

  • Sleeping problems (insomnia), strange dreams
  • Headache, Dizziness, Drowsiness, Vision Changes
  • Trembling or shaking, feeling anxious or nervous
  • Pain, weakness, yawning, feeling tired
  • Stomach upset, loss of appetite, nausea, vomiting, diarrhoea
  • Dry mouth, sweating, hot flashes
  • Changes in weight or appetite
  • Stuffy nose, sinus pain, sore throat
  • Decreased sex drive, impotence or difficulty having an orgasm


This is not a complete list of side effects and other side effects may occur. Call your doctor for medical advice on any side effects.


In what dosages is Prozac prescribed?

Take Prozac exactly as prescribed by your doctor. Follow all directions on your prescription label and read any medication guides or instruction sheets. Your doctor may change your dose from time to time.

You should not crush, chew, break, or open a Prozac delayed-release tablet. Swallow the tablet whole.

It may take up to 4 weeks for your symptoms to improve. Continue to take the medication as prescribed and tell your doctor if your symptoms do not improve.

Do not suddenly stop taking Prozac or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop taking this medicine.


What drugs or supplements does Prozac interact with?

Prozac can cause a serious heart problem. Your risk may be higher if you also take certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria or HIV.

Taking Prozac with other drugs that make you sleepy can make this effect worse. Ask your doctor before taking opioid medications, a sleeping pill, a muscle relaxer, or medications for anxiety or seizures.

Before taking a nonsteroidal anti-inflammatory drug such as aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), diclofenac, indomethacin, meloxicam, and others, tell your doctor. Taking a pain reliever along with Prozac can cause you to bruise or bleed easily.

Tell your doctor about all your current medicines. Many drugs can interact with Prozac, especially:

  • Any other antidepressant
  • St. John's wort
  • Tryptophan (sometimes called L-tryptophan)
  • A blood thinner such as warfarin, Coumadin, Jantoven
  • Medicines for anxiety, mood disorders, thought disorders, or mental illness such as amitriptyline, buspirone, desipramine, lithium, nortriptyline, and many others
  • Drugs to treat ADHD or narcolepsy such as Adderall, Concerta, Ritalin, Vyvanse, Zenzedi, and many others
  • Migraine medications such as rizatriptan, sumatriptan, zolmitriptan and many others
  • Numbing pain medications such as fentanyl, tramadol

This list is not exhaustive and many other drugs can interact with Prozac. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.


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