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The Levitra brand was developed by the pharmaceutical company Bayer/GlaxoSmithKline and uses Vardenafil HCl as the main ingredient of the drug. Levitra is an oral medicine used to treat erectile dysfunction. Sexual stimulation triggers the production and release of nitric oxide from the nerve endings of the cavernous bodies of the penis, activating the enzyme guanylate cyclase. Guanylate cyclase, in turn, is responsible for the production of cyclic guanosine monophosphate (cGMP). The cGMP widens and relaxes the blood vessels that carry blood to the penis. Levitra prevents the enzyme phosphodiesterase-5 from destroying the cGMP, thus helping to support blood flow to the penis.
The recommended dose of Levitra is 10 mg per day, taken one hour before intercourse. If no side effects are experienced, the dosage can be increased to 20 mg. In case of side effects, the dose is reduced to 5 mg per day. Do not take more than one Levitra tablet per day.
Levitra has not been studied in people with cardiovascular disease, so it is preferable to avoid Levitra in patients who have had a stroke or heart failure, or a history of heart attack, especially in the last six months. Before taking Levitra, tell your doctor if you have kidney or liver problems, a bleeding disorder, stomach ulcer, or hereditary retinal disease such as retinitis pigmentosa, allergic reaction to this medicine or other medicines, penile deformity such as angulation, cavernous fibrosis (Peyronie's disease ), as well as in diseases that contribute to the development of priapism (sickle cell anemia, multiple myeloma, leukemia, or leukemia).
Levitra is contraindicated in patients with hypersensitivity to its components, in patients treated with organic nitrates, in patients under 16 years of age, and in patients taking HIV protease inhibitors such as indinavir and ritonavir.
Levitra is usually well tolerated and if side effects do occur they are transient. The most common side effects are headache, flushing (person's hyperemia); frequent; dizziness, diarrhea, nausea, nasal congestion. More rare and uncommon side effects are skin photosensitivity, hypertension, back pain, watery eyes, hypotension, myalgia, priapism.
The metabolism of Levitra is inhibited by erythromycin, ketoconazole (Nizoral), itraconazole (Sporanox), indinavir (Crixivan), and ritonavir (Norvir). Levitra decreases the concentration of ritonavir and indinavir. In patients treated with nitrates, Levitra may worsen chest pain by increasing heart rate and lowering blood pressure. Levitra may enhance the blood pressure lowering effects of alpha-blocking drugs (terazosin or Hytrin). Levitra should never be administered to patients being treated with organic nitrates.
Levitra is taken when needed, but no more than once a day, so a missed dose is not assumed.
Overdose symptoms include pain in the back, jaw, arm, blindness, blurred vision, chest pain or discomfort, decreased vision, blurred vision.
Store at room temperature between 15-30 C (59-86 F) away from children, pets, moisture and sunlight.
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