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Varenicline, also known by its brand name Champix, is a medicine that helps people to quit smoking. The majority of smokers would like to let go of cigarettes or tobacco. One of the main reasons many struggle with this is because nicotine is addictive. Soon after your last toke, you may experience withdrawal symptoms. Varenicline (Champix®) can help you with this.
Varenicline (Champix®) is a medicine that was first authorized in the United Kingdom in December 2006. It was developed to help smokers quit. Varenicline mimics the effect of nicotine on the body. Therefore, it reduces the urge to smoke as well as the withdrawal symptoms associated with quitting.
Varenicline works by disrupting receptors in the brain that stimulate nicotine. (The nicotine in cigarettes attaches to the receptors in the brain cells to stimulate part of the brain. What varenicline does is partially stimulate the nicotine receptors. This mimics the effects of nicotine to reduce cigarette cravings and withdrawal symptoms. when you stop smoking, but at the same time it partially blocks the receptors and prevents nicotine from attaching to the receptors, which blocks or blunts the effect of nicotine in people who give in to temptation and smoke a cigarette.
If you take Champix:
Each capsular tablet is white to off-white with “Pfizer” written on one side and “CHX 0,5” on the other. This means that each tablet contains 0,5 mg of varenicline (as tartrate).
Each capsule shaped tablet has a light blue color and is coated with folate. “Pfizer” is written on one side of the tablet and “CHX 1.0” on the other side. This means that this pill contains 1 mg of varenicline (as tartrate).
Varenicline increases the chance of successfully quitting smoking. This has been effectively investigated in some studies. Studies have compared varenicline to a dummy (placebo tablet) in people eager to let go of cigarettes or tobacco. The results of the studies showed that 21 out of 100 people have successfully used varenicline to quit. This compared to about 8 in 100 people who took the dummy tablets. In other words, taking varenicline more than doubled the chances of success.
Varenicline alone will not make you quit smoking. You still need determination to succeed in breaking your habits. A combination of varenicline with supervision by a nurse, doctor, pharmacist or other health professional does increase your chance of a successful smoking stop. Therefore, most doctors will only prescribe varenicline to people who really want to quit smoking as part of a program or plan.
The usual duration of treatment is 12 weeks. If you have successfully quit smoking by then:
Most people who use varenicline have no or only minor side effects. However, it is strongly recommended that you read the information that comes with the medicine for a full list of possible side effects. Caution is always advised. The most common and possibly most serious side effects are highlighted below.
The most commonly reported side effects are nausea (nausea). This is often mild and tolerable. Nausea is considered less of a problem if you take the tablets with a full glass of water immediately after a meal. Some other side effects reported in some people are sleep problems (insomnia), abnormal dreams, headache and flatulence. Taking the evening dose after dinner, and not just before going to bed, may reduce the side effects of sleep.
Varenicline can also affect your ability to drive and use machines. You shouldn't drive or operate complex machinery or participate in potentially dangerous activities until you know how varenicline affects you.
In June 2011, the United States Food and Drug Administration (FDA) warned that varenicline may increase the risk of heart complications (such as heart attack) in people with existing cardiovascular disease. (Cardiovascular diseases are diseases of the heart or blood vessels, such as angina or peripheral vascular disease). The warning was based on a study that followed 700 smokers who suffered from cardiovascular disease and were treated with varenicline. The results of the study confirmed that varenicline was effective in helping people to quit smoking. Also, adverse cardiovascular events such as heart attack were generally uncommon. However, certain cardiovascular events, including heart attack, were slightly more common in people taking varenicline than those treated with placebo.
However, the increased risk of cardiovascular disease was not statistically significant. (That is, the small increased number of cardiovascular events may have happened by chance.) More recent research has found no evidence that varenicline causes an increase in cardiovascular events such as heart attack.
After its introduction, there were several reports of a possible association between varenicline and behavior or mood changes. Suspected symptoms included hostility, agitation, depressed mood, suicidal thoughts and suicide attempts. The manufacturer was commissioned by the US FDA to conduct a large randomized control trial in more than 8.000 people to specifically look at this issue. The results were published in 2016 and showed no increase in mental health symptoms in humans on any of the smoking cessation treatments, including with the use of varenicline. The European Medicines and Healthcare products Regulatory Agency (MHRA) and the FDA have now removed their warnings regarding varenicline and behavioral or mood changes. The FDA states that the results of the study confirm that the benefits of quitting smoking outweigh the risks of these drugs.
Varenicline is generally considered a safe drug for most people. However, it is a relatively new drug and therefore caution is advised in certain people. For example, it is not approved for use in people who are pregnant or breastfeeding, people under the age of 18, and people with severe kidney failure. Your doctor or practice nurse will advise whether or not you are suitable for this medicine. If you are unable to take varenicline, there are other ways you can get help to quit.
If you still feel that Champix is not for you or if you are not quite ready to quit, there are alternative options such as:
If you really want to quit, you can buy Champix. It is one of the most effective ways because it triples the chances of success compared to other tools. Another advantage why you should buy Champix is because it contains no nicotine. Some substitutes such as patches, inhalers and sprays contain nicotine and help people quit smoking. However, it does not help them from their nicotine addiction. Hence, this medicine is much better than all other different tools and techniques.
Whether you buy Champix via the internet or through your regular pharmacy is your decision. Be aware that buying Champix on the internet can save you considerable time and money. If you choose the internet, you can buy Champix from the comfort of your home or office and with the necessary privacy. However, we do recommend ordering it from a safe and reliable source such as Onlineapotheek.co.
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